10-year-old Pixote endures torture, degradation, and corruption at a local youth detention center where two of its members are murdered by policemen who frame Lilica, a 17-year-old trans hustler. Pixote helps Lilica and three other boys escape and they start to make their living by a life of crime which only escalates to more violence and death.

In 1980s Italy, a relationship begins between seventeen-year-old teenage Elio and the older adult man hired as his father's research assistant.