After his young lover, Gitone, leaves him for another man, Encolpio decides to kill himself, but a sudden earthquake destroys his home before he has a chance to do so. Now wandering around Rome in the time of Nero, Encolpio encounters one bizarre and surreal scene after another.

Melanie Parker, an architect and mother of Sammy, and Jack Taylor, a newspaper columnist and father of Maggie, are both divorced. They meet one morning when overwhelmed Jack is left unexpectedly with Maggie and forgets that Melanie was to take her to school. As a result, both children miss their school field trip and are stuck with the parents. The two adults project their negative stereotypes of ex-spouses on each other, but end up needing to rely on each other to watch the children as each must save his job. Humor is added by Sammy's propensity for lodging objects in his nose and Maggie's tendency to wander.

Hapless museum night watchman Larry Daley must help his living, breathing exhibit friends out of a pickle now that they've been transferred to the archives at the Smithsonian Institution. Larry's (mis)adventures this time include close encounters with Amelia Earhart, Abe Lincoln and Ivan the Terrible.

After her triumph at the Miss United States pageant, FBI agent Gracie Hart becomes an overnight sensation -- and the new "face of the FBI". But it's time to spring into action again when the pageant's winner, Cheryl, and emcee, Stan, are abducted.

In the opening chase, Martin Riggs and Roger Murtaugh stumble across a trunk full of Krugerrands. They follow the trail to a South African diplomat who's using his immunity to conceal a smuggling operation. When he plants a bomb under Murtaugh's toilet, the action explodes!