After their first adventure with the Hot Tub Time Machine, Lou and Nick are living very well off their ill-gotten gains, while Jacob still cannot rely on Lou to be a positive role model. When an unknown assailant breaks into Lou's mansion and shoots him, Nick and Jacob take him for another trip in the hot tub. They emerge in the year 2025, where they must figure out who shot Lou and prevent it from happening again.

A true immigrant story set against the vibrant backdrop of Flushing, N.Y. in the 1980s and 1990s.

A successful Texas gynecologist finds himself amid a bevy of women and their problems – his wife’s breakdown, his daughter's fake marriage, his other daughter’s conspiracy theories, and his secretary’s crush. Craving time for himself, he finds solace in a kind outsider.

Medical researcher Frank, his fiancee Zoe and their team have achieved the impossible: they have found a way to revive the dead. After a successful, but unsanctioned, experiment on a lifeless animal, they are ready to make their work public. However, when their dean learns what they've done, he shuts them down. Zoe is killed during an attempt to recreate the experiment, leading Frank to test the process on her. Zoe is revived -- but something evil is within her.