Professor Phillip Goodman devotes his life to exposing phony psychics and fraudulent supernatural shenanigans. His skepticism soon gets put to the test when he receives news of three chilling and inexplicable cases -- disturbing visions in an abandoned asylum, a car accident deep in the woods and the spirit of an unborn child. Even scarier -- each of the macabre stories seems to have a sinister connection to the professor's own life.

Scooby-Doo and his pals win an all-expense paid vacation and embark on a trip of a lifetime to a tropical paradise. Their destination however, turns out to be Zombie Island. As soon as they arrive, they realize the place looks strangely familiar and is reminiscent of a trip they took years ago, in which they became wrapped up in a mystery involving zombies. The gang soon learns that their trip to paradise comes with a price when the zombies re-emerge and attack their hotel. Will Scooby-Doo and the Mystery Inc. gang finally solve the mystery behind Zombie Island?