In an effort to prevent family history from repeating itself, meddlesome mom Daphne Wilder attempts to set up her youngest daughter, Milly, with Mr. Right. Meanwhile, her other daughters try to keep their mom's good intentions under control.

While visiting her sister in Paris, a young woman finds romance and learns her brother-in-law is a philanderer.

Climbing aboard their mammoth recreational vehicle for a cross-country road trip to the Colorado Rockies, the Munro family – led by dysfunctional patriarch, Bob – prepares for the adventure of a lifetime. But spending two weeks together in one seriously small space has a way of cramping their style.

When he finds out his longtime girlfriend is pregnant, a commitment-phobe realizes he might have to change his lifestyle for better or much, much worse.

Grace King Bichon, who is managing her father's riding-stable, discovers that her husband Eddie is deceiving her with another woman. After confronting him in the middle of the night on the streets of their small home town, she decides to stay at her sister Emma Rae's house for a while to make up her mind. Breaking out of her everyday life, she starts to question the authority of everyone.

Jimmie is seeing his single friends get married one by one. He isn't too worried until his girlfriend Anne catches the bouquet at his friend Marco's wedding. Suddenly, his wild mustang days are numbered. He finally decides to propose to her, but he sticks his foot in his mouth and botches the proposal. Being insulted by the defeatist proposal, Anne leaves town on an assignment. After she's gone, he finds out that his recently-deceased grandfather's will stipulates that he gets nothing of a multi-million dollar fortune unless he's married by 6:05pm on his 30th birthday: tomorrow! Not being able to find Anne, Jimmie begins backtracking through his past girlfriends to find a wife.

Charlie and Dan have been best friends and business partners for thirty years; their Manhattan public relations firm is on the verge of a huge business deal with a Japanese company. With two weeks to sew up the contract, Dan gets a surprise: a woman he married on a drunken impulse nearly nine years before (annulled the next day) shows up to tell him he's the father of her twins, now seven, and she'll be in jail for 14 days for a political protest. Dan volunteers to keep the tykes, although he's up tight and clueless. With Charlie's help is there any way they can be dad and uncle, meet the kids' expectations, and still land the account?

Christmas Eve in New York, and the lonely divorced publisher, Rose Collins, needs a miracle to improve the health of her mother, interned in a hospital with Alzheimers. She feels sorry for another patient and meets his visitor. Meanwhile, Nina Vasquez breaks her engagement with her beloved fiancé Mike due to his suffocating jealousy, but misses him. Mike is stalked by a stranger, bartender Artie Venzuela. The poor Jules arranges to spend Christmas Eve in the hospital, where he spent the best Christmas of his life when he was a teenager. The lives of some of these characters cross with others along the night.

Three young boys pool their money and pay V, a kindhearted prostitute, to strip for them. Afterward, she drives them home to the suburbs -- but then her car breaks down. It's just as well, though, because a mobster named Waltzer is after her, and V realizes the suburbs are the perfect place to hide. But things get a lot more complicated when V falls in love with Tom, a single father who is unaware of her real profession.