Taking place after the events of Assassin's Creed: Revelations in the year 1524 in Tuscany, follow the retired Assassin Ezio Auditore as he teams up with Shao Jun during his final battles.

A terrorist Muslim group calls for the execution of Sheikh Hassan for refusing to join their organisation. At the same time, a priest ,Marcos, is also facing death threats. Both men seek help from the government, who puts them under the witness protection program, giving each man the other's identity.

Abboud lives a reckless life with his two friends. He knows that he will not enter the army because he's an only child. But when his father marries another woman who gives birth to a boy, Abboud is forced to join the army in spite of being unfit, working at the border with his friends.

Shawaf delivers his neighbor Fatima an illustrative map of the ship sunken at the Devil Island in Hurghada, hidden by gold boxes, accompanied by Baybars to finance the trip, and agree to Jalal teach them to dive, and recognizes the task of Fatima, and succeeded in the extraction of some gold bars, and here shows the Zoghbi gang and events escalate.

Sharif, his wife Su'ad, their daughter Sarah, their son Hany and his mother are all living in the shelters after their house was demolished. Due to the inhumane standard of living in the shelters, they go to live in the courtyard of the family house. Unfortunately they find another person living there. Sharif designs and builds a wooden cabin to live in the street. He is subjected to many harassment.

Lady Bird McPherson, a strong willed, deeply opinionated, artistic 17 year old comes of age in Sacramento. Her relationship with her mother and her upbringing are questioned and tested as she plans to head off to college.