With the space program attempting to travel to Mars, 21st century scientists were tasked with warming up the planet so that humans could survive on its surface. They came up with an efficient and cost effective plan of sending cockroaches and mold to the surface so that the mold would absorb the sunlight and the insect corpses would serve as a food source for the mold. It is now the year 2577 and the first manned ship to Mars has landed on the planet and the six crew members are ready for their mission. But what they find are giant mutated humanoid cockroaches with incredible physical strength. The crew members are easily wiped out, but not before sending a transmission back to Earth. Now, humanity will send elite warriors to exterminate the mutated bugs and claim back Mars.

This time, the rivals team up to help a cowgirl and her brother save their homestead from a greedy land-grabber, and they’re going to need some help! Jerry’s three precocious nephews are all ready for action, and Tom is rounding up a posse of prairie dogs. But can a ragtag band of varmints defeat a deceitful desperado determined to deceive a damsel in distress? No matter what happens with Tom and Jerry in the saddle, it’ll be a rootin’ tootin’ good time!