Spanning over one thousand years, and three parallel stories, The Fountain is a story of love, death, spirituality, and the fragility of our existence in this world.

Aging wrestler Randy "The Ram" Robinson is long past his prime but still ready and rarin' to go on the pro-wrestling circuit. After a particularly brutal beating, however, Randy hangs up his tights, pursues a serious relationship with a long-in-the-tooth stripper, and tries to reconnect with his estranged daughter. But he can't resist the lure of the ring and readies himself for a comeback.

Young Native American man Thomas is a nerd in his reservation, wearing oversize glasses and telling everyone stories no-one wants to hear. His parents died in a fire in 1976, and Thomas was saved by Arnold. Arnold soon left his family, and Victor hasn't seen his father for 10 years. When Victor hears Arnold has died, Thomas offers him funding for the trip to get Arnold's remains.

In the distant future, Earth is occupied by ancient gods and genetically altered humans. When a god is sentenced to death he seeks a new human host and a woman to bear his child.