A Tokyo college student is attacked by a ghoul, a super-powered human who feeds on human flesh. He survives, but has become part ghoul and becomes a fugitive on the run.

While combing through the belongings of his recently deceased aunt, Matsuko, nephew Sho pieces together the crucial events that sank Matsuko's life into a despairing tragedy.

In 1980s Italy, a relationship begins between seventeen-year-old teenage Elio and the older adult man hired as his father's research assistant.