A teenager's disappearance causes her family's world to turn upside down. In the police quest to find her, all her relatives will become suspects of her kidnapping.

A Corazón Abierto is a Colombian television series based on ABC's hit show Grey's Anatomy, written and supervised by Colombian writer Fernando Gaitan better known for creating hit telenovelas like Yo soy Betty, la fea, Café con Aroma de Mujer, and Hasta que la Plata nos Separe. Initially conceived as a weekly series, the story was modified to be aired 5 episodes a week in a telenovela format, that is why several changes have been made into the story. The series began airing in the United States weeknights at 7pm on Telemundo on May 17, 2010.

After causing the death of her millionaire husband Carlos, Catalina Creel, whose great beauty is only surpassed by her cruelty, will go to any lengths to secure her fortune and bloodline.

A woman decides to become a "pre-paid" prostitute to raise the required money for a surgery to increase her breast size, and that way, change her poor-life-style, her present and her future.

The series follows the fun and endearing Derbez family as they discover new cultures in foreign lands and for the first time – all together and unfiltered.