My fortune is loving you tells the story of Natalia and Chente, who both suffer different situations that change their lives instantly. Natalia comes from a high social position; however, she loses everything when Adrián, her husband, leaves her for what was "her best friend" after 20 years of marriage, in addition, he leaves her on the street and penniless. Vicente, from a different socioeconomic class than Natalia, falls into the hands of a financial fraud that also leaves him in a very difficult economic situation, adding the recent loss of Lucía, his wife, at the hands of a bank robbery in which she was. For Natalia and Chente, they have no choice but to live under the same roof, with which, upon meeting the relationship, they will go through a lot of ups and downs of emotions when they try to resolve their personal situations.

As a child, Masamune Makabe once suffered greatly at the hands of a wealthy and beautiful girl named Aki Adagaki, who nicknamed him "Piggy" due to his chubby appearance. Seeking revenge against his tormentor, Masamune works hard to improve himself and returns as an incredibly handsome, albeit narcissistic, high school student. When he encounters Aki once again, he is prepared to exact vengeance. With the aid of the rich girl's maid, Yoshino Koiwai, Masamune slowly begins to build his relationship with Aki, intending to break her heart when the time is right. However, as his friendship with Aki begins to grow, Masamune starts to question the objectives of his devious plans, and if bringing them to fruition is what his heart truly desires.