The lives of a college student and a video game designer are kept being reset after an explosion on a bus. During each reset, they have to work together to find out what the reason for the explosion is. Will these two be able to save themselves and their fellow passengers? Will they be able to close the time-loop?

Set against the backdrop of massive economic growth in the 1990s, the story follows A Bao, a self-made millionaire and his journey from being a young opportunist with a troubled past to accumulating dazzling wealth in the city of Shanghai. It also follows his entanglement with four women who represent the pursuits of his life: adventure, honour, love and innocence.

Nanotechnology researcher Wang Miao is taken to the Joint Operations Center by police officer Shi Qiang, who's investigating the mysterious suicide wave among scientists worldwide, and recruited to sneak into an organization called the Frontiers of Science to help the investigation. When Wang Miao is contacted by the leader of the organization, Shen Yufei, she introduces him to a sophisticated VR video game called Three-Body, but soon he discovers that it's more than just a game.

Surgeon Henry Johnsen starts a secret battle to find a cure for an incurable brain tumor he was diagnosed with. As he struggles to maintain his usual superiority over his patients and colleagues, is it finally time to come clean?