Narumi Fujishima is an ordinary high school boy who remains isolated from his fellow classmates. One afternoon fellow classmate Ayaka Shinozaki invites Narumi to join the gardening club and introduces him to a reclusive detective named Alice. Alice hires Narumi as an assistant and puts him to work solving the strange mysteries of Angel fix, an illegal drug. Little does he know it could put him and Ayaka in serious trouble.

High school girl Maika Sakuranomiya has trouble finding a part-time job because of how scary she looks when smiling. However, she is scouted one day by Dino, the manager of the café Stile where its waitresses play unique traits such as tsundere and younger sister. Maika is given a sadist trait because of her looks and has to adopt a dominant and cruel persona when servicing customers, particularly masochist ones.

Taking place mainly in Bogotá, Colombia, Betty La Fea is essentially a Cinderella comedy about the rise of poor, ugly 'Betty' Pinzón and the fall of rich, handsome Armando Mendoza. Armando is a very incompetent playboy with a scheme to turn a huge profit as the new President of Eco Moda, a famous clothing manufacturing company, but his scheme is doomed because of his faulty mathematics. Because Betty, his secretary (and economics wizard), is in love with him, she helps Armando deceive the Board of Directors as he loses money and brings the company to ruin. Betty, la Fea is arguably the most successful telenovela of all time and one of the most popular television shows in the world. It is the first telenovela to have been remade worldwide and has been regarded as bringing the telenovela to new levels of success.